Longyu Supply Top Quality Calcium Folinate 1492-18-8

• CAS No.: 1492-18-8
• Formula: C20h21can7o7
• Environmental Protection: Yes
• Certification: GMP
• Color: White
• Classification: Vitamin
• Function: Feed Processing and Preservation Agent
• Appearance: Powder
• Transport Package: Aluminum Foil Package
• Specification: 1kilogram
• Trademark: NA
• Origin: China
• Production Capacity: 10000grams/Month

Product Description

Basic Information:
Product Name: Calcium Folinate
Molecular Formula: C20H21CaN7O7
Molecular Weight: 511.5
CAS Registry Number: 1492-18-8
EINECS:  216-082-8
Melting point: 245°C

Product Description:
Folinic acid (INN) or leucovorin (USAN), generally administered as calcium or sodium folinate(or leucovorin calcium/sodium), is an adjuvant used in cancer chemotherapy involving the drug methotrexate. It is also used in synergistic combination with the chemotherapy agent 5-fluorouracil.
Folinic acid was first discovered in 1948 as citrovorum factor and occasionally is still called by that name. Folinic acid should be distinguished from folic acid (vitamin B9). However, folinic acid is a vitamer for folic acid, and has the full vitamin activity of this vitamin. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Function:
Folinic acid is administered at the appropriate time following methotrexate as part of a total chemotherapeutic plan, where it may "rescue" bone marrow and gastrointestinal mucosa cells from methotrexate. No apparent effect is seen on pre-existing methotrexate-induced nephrotoxicity. Folinic acid can be taken as a pill (orally) or injected into a vein (intravenously) or muscle (intramuscularly). 
While not specifically an antidote for methotrexate, folinic acid may also be useful in the treatment of acute methotrexate overdose. Different dosing protocols are used, but folinic acid should be redosed until the methotrexate level is less than 5 x 10−8 M.
Additionally, folinic acid is sometimes used to reduce the side effects of methotrexate in rheumatoid arthritispatients. This includes reductions in nausea, abdominal pain, abnormal liver blood tests, and mouth sores. 
Folinic acid is also used in combination with the chemotherapy agent 5-fluorouracil in treating colon cancer. In this case, folinic acid is not used for "rescue" purposes; rather, it enhances the effect of 5-fluorouracil by inhibiting thymidylate synthase.
Folinic acid is also sometimes used to prevent toxic effects of high doses of antimicrobial dihydrofolate reductase inhibitors such as trimethoprim and pyrimethamine. It may be prescribed in the treatment oftoxoplasmosis retinitis, in combination with the folic acid antagonists pyrimethamine and sulfadiazine.
Folinic acid has dextro- and levorotary isomers, only the latter one being pharmacologically useful. As such, levoleucovorin was approved by the Fin 2008.
 

FAQ
Application Area:
Uridine 5-Mophosphate Disodium are produced through the hydrolytic reaction from Ribonucleic acid(RNA) as raw material by enzymatic catalysis to form four kinds of nucleotides 5- 'AMP (adenosine-5'-monophosphate), 5'-GMP•2Na(guanosine-5'-monophosphate, disodium salt), 5'-CMP(cytidine-5'-monophosphate)-, 5'-UMP•2Na (uridine- 5'-monophosphate,Disodium salt) .By the chromatographic isolation, four kinds of separated 5'-nucleotide products with high purity can be obtained. These products can be widely applied in medicine, reagent, fine chemical industry, and additive of food fields etc.

1:  How to start orders or make payments?

You can send your Purchase order, or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma
Invoice with our bank details for your confirmation, then you can make payment accordingly.

2:  How to make the payment?
We can accept L/C, T/T, West Union, Money Gram etc.

3: What's your MOQ?
For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low price product, our MOQ starts from 100g and 1kg.

4:  When will you deliver the goods?
If we have inventory, generally we can arrange shipment after receipt of payment 2 to 3 days. If not, it will be decided by the time of the factory production.


Our advantages
1.High quality with competitive price.
2. All purity>99%.
3. We are manufacturer and can provide high quality products with factory price.
Fast and safe delivery.

1. Parcel can be sent out in 24 hours after payment tracking number available.
2. Secure and discreet  shipment verious transportation methods for your choice.
3. Customs pass rate >99%.
4. We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

We have clients throughout the world.
1. Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2. Market feedback and goods feedback will be appreciated , meeting customers' requirement is our responsibility.
3. High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
5.Sample order are welcome.
6.NMR,HPLC and COA can be supplied
7.We can supply sample for testing
8.We promise 100% deliveried,and 100% resend or refunds if parcel is not deliveried!